Gyros Protein Technologies PPX-110 Prelude X Peptide Synthesizer
The design power of the proprietary PurePep Pathway (valve block system) results in zero dead volumes, no cross-contamination, and worry-free performance that lasts for years. Other systems use off-the-shelf valves that leak, cross-contaminate, and quickly fail when exposed to harsh peptide synthesis chemicals. With the trusted PurePep Pathway inside Prelude X, you have reliable peptide purity every time.
Prelude X is the first instrument of its kind to include rapid induction heating. Heating conditions in each of the six reaction vessels (no resin loader required) can be independently set to enable flexible, customized syntheses. The patent-pending technology takes just seconds to reach temperature, does not result in temperature overshooting and enables controlled heating between 25°C and 90°C. The technology is fully-compatible with oscillation mixing, which ensures even temperature profiles, homogenous chemistry, and high yields.
All six reaction vessels on the Prelude X instrument are equipped with oscillation mixing. This method creates a uniform heating profile throughout the reaction vessel, eliminating the potential for hot spots or burnt resins. Additionally, it functions to keep resins off the side walls and submerged within the solution. Combined with the fully adjustable nitrogen mixing that is also included on each reaction vessel, Prelude X allows complete control of reaction parameters for precise and reproducible peptide synthesis.
Minimize trial-and-error when synthesizing difficult peptides using the Intellisynth real-time UV monitoring on Prelude X. What makes our UV monitoring different? Other systems just monitor the waste stream. We monitor your reaction solution while it’s mixing – that’s why we’re the only ones who can control the deprotection reaction times, not just the number of repetitions. When using Single-ShotTM amino acid delivery, real-time UV monitoring ensures that reactions are completed efficiently and no excess reagent is wasted.
Prelude X has the ability to run three preactivation reactions in parallel. This is ideal for sterically hindered amino acid additions. Additionally, DIC/HOBt chemistry can be optimized and go straight to scale-up.
Installation qualification and operation qualification (IQ/OQ) support services verify and document that your instrument is supplied, installed, and operating according to GPT specifications, and may be required for operating under cGMP conditions. GPT-certified field service engineers inspect critical components, ensure that your systems function properly and reproducibly during automated synthesis operations, and provide documentation to help you meet regulatory requirements.