Listing# 644938

Refurbished Waters SYNAPT HDMS Q-TOF Mass Spec with Waters Acquity UPLC including 60-day Warranty

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$50,000.00 USD

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Location:  MA, USA

Level of Removal:  Uncrated/Loose

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60 Day Warranty Included!

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Equipment Description
Refurbished Waters SYNAPT HDMS Q-TOF Mass Spectrometer and Waters Acuity UPLC including 60-day Warranty!

This system was fully refurbished and set up by certified engineers. Inspection and single sample testing is available for interested buyers. Attached is a full report of the instrument testing and reporting after refurbishment was complete. This instrument is in excellant condition!

• Waters Synapt G1 HDMS Mass Spectrometer
• Waters Column Heater
• Waters Acquity Sample Manager
• Waters Acquity Binary Solvent Manager
• Waters Acquity TUV Detector
• Waters Flex Cart
• Waters Sample Tray
• Edwards XDS 35i pump
• All tubing and connections
• Computer with software (no license)
• 60-day warranty (within the USA) (review warranty for terms and conditions)
• Professional crating of instrument

Detailed Description:

The Waters SYNAPT HDMS Q-TOF Mass Spectrometer (QTOF LCMSMS MSD G1 High Definition Mass Spectrometry Quadruple Time of Flight ) is designed for leading researchers working at the limits of conventional mass spectrometry capabilities who need to further characterize and define their samples, Waters SYNAPT HDMS System offers unique, enabling functionality. Waters SYNAPT HDMS System enables the analysis of samples differentiated by size and shape, as well as mass, to deliver increased specificity and sample definition beyond that achievable by conventional mass spectrometers. System Includes:

TOF Mass Resolution in Positive Ion
a) V Mode: 10,000 measured on the (M + 6H)^6+ isotope cluster from bovine insulin (m/z 956)
b) W Mode: 17,500 measured on the (M + 6H)^6+ isotope cluster from bovine insulin (m/s 956)
TOF Mass Resolution in Negative Ion
a) V Mode: 10,000 measured on the (M - 4H)^4- isotope cluster from bovine insulin (m/z 1431)
b) W Mode: 17,500 measured on the (M - 4H)^4- isotope cluster from bovine insulin (m/z 1431)
Positive Ion MS Sensitivity
a) V Mode: The peak at m/z 556 from a solution of 50 pg/µL leucine enkephalin in 50/50 acetonitrile/water + 0.1% formic acid, infused at a flow rate of 5 µL/min, will have an intensity of greater than 1,700 counts per second. The instrument will be tuned to 10,000 resolution (as demonstrated on bovine insulin) and the mass range will be set to 1,000 Da.
b) EDC: The peak at m/z 556 from a solution of 10 pg/µL leucine enkephalin in 50/50 acetonitrile/water + 0.1% formic acid, infused at a flow rate of 5 µL/min, will have an intensity of greater than 2,000 counts per second. The instrument will be tuned to 10,000 resolution (as demonstrated on bovine insulin), with sensitivity set to a maximum at 556 Da.
Negative Ion MS Sensitivity:
V Mode: The peak at m/z 503 from a solution of 500 pg/µL raffinose in 70/30 acetonitrile/water (no additives), infused at a flow rate of 5 µL/min, will have an intensity of greater than 1,800 counts per second. The instrument will be tuned to 10,000 resolution (as demonstrated on bovine insulin), and the mass range will be set to 1,000 Da.
Positivt Ion MS/MS Sensitivity
V Mode: Using a [Glu]-Fibrinopeptide B solution of 100 fmol/µL, at a flow rate of 5 µL/min and with the instrument tuned for 10,000 resolution (as demonstrated on bovine insulin), the intensity of the most intense y" sequence ion from the MS/MS spectrum of the doubly charged precursor ion (785.8 Da) will be greater than 130 counts per second. This will correspond to a signal to noise ratio of greater than 50:1 (after a 3x9 smooth) on the most intense y" sequence ion, for a 1 second scan. The instrument mass range will be set to 2,000 Da.
Negative Ion MS/MS Sensitivity
V Mode: Using a solution of 500 pg/µL raffinose in 70/30 acetonitrile/water, at a flow rate of 5 µL/min and with the instrument tuned for 10,000 resolution (as demonstrated on bovine insulin), the intensity of the fragment ion at 179.1 Da in the MS/MS spectrum of the precursor ion at 503.2 Da will be greater than 130 counts per second. The instrument mass range will be set to 1,000 Da.
Mass Scale Calibration Accuracy
The mass measurement accuracy of the instrument in V-mode, using an internal lockmass, is such that the RMS error between the measured and the accepted masses of peaks which have sufficient intensity, and are free from interference from other masses, will be less than 2 ppm over the range of 150-900 Da.
Mass Measurement Accuracy
The mass measurement accuracy of the instrument, in W-mode, will be better than 2 ppm RMS, based on 10 consecutive repeat measurements of the [M + Na]^+ ion of raffinose (m/z 527.1588), using the [M + H]^+ ion of leucine enkephalic (556.2771) as the LockSpray lockmass. Analyte lockmass peaks must have sufficient intensity and be free of interference from other masses.
Mass Range
The TOF mass range is 20 - 100,000 Da in V-mode, and 20 - 26,500 Da in W-mode.
The quadrupole mass range in non-resolving mode is 20 - 16,000 Da for a 4,000 Da quadrupole, and 20 - 32,000 Da for an 8,000 Da quadrupole.

The ACQUITY UPLC System will eliminate significant time and cost per sample from your analytical process while improving the quality of your results. By outperforming traditional or optimized HPLC, the system allows chromatographers to work at higher efficiencies with a much wider range of linear velocities, flow rates, and backpressures. UPLC Technology, which has been adopted successfully in laboratories around the world for the most demanding separations, is a highly robust, dependable, and reproducible system. What differentiates the system’s holistic design is Waters’ patented sub-2-µm hybrid particle chemistry, which offers significant benefits over today's HPLC systems equipped with standard 5-µm particle chemistries. The ACQUITY UPLC System, used on its own or paired with Waters optical and MS detection technologies, provides unique end-to-end solutions for all industries:
• ADME screening
• Food safety
• Bioanalysis
• Clinical
• Metabolite identification
• Metabonomics
• Method development
• Open access
• Routine quality screens
The system also routinely handles demanding applications such as the turnkey solutions built for amino acid and peptide analyses. It is compliant with strict regulatory guidelines for clinical applications.
System includes:
• ACQUITY UPLC Sampler Manager
• ACQUITY UPLC Column Heater
• ACQUITY UPLC Binary Solvent Manager
• Computer

Waters Acquity UPLC with Tunable UV (TUV) Detector
The ACQUITY UPLC TUV Detector provides performance benefits for both routine and complex analyses in pharmaceutical, life science, environmental, agricultural, energy, and petrochemical applications. The Detector is a tunable, dual wavelength ultraviolet/visible (UV/Vis) detector that offers optimal linearity, resolution, and sensitivity for UPLC/UV separations. It features uniquely designed, patented, light-guiding flow cell technology, low-noise performance (6 µAU), and support for data rates up to 80 Hz.
• Maximum signal-to-noise response enabled by light-guiding flow cell technology, which eliminates internal absorption, for minimal bandspreading and maintained concentration
• High sensitivity for low-level detection for simultaneous quantitation of major and minor components
• Intuitive set-up, monitoring, and diagnostics with a customizable instrument console for both Empower and MassLynx Software
• Independent optimization of data rate and filter time constants for the accurate integrations of narrow, sharp peaks typically characterized by UPLC and resolution that are unprecedented in HPLC techniques being used in the laboratory today.
Wavelength range 190 to 700 nm
Light source Deuterium arc lamp
Bandwidth 5 nm
Wavelength accuracy ±1 nm
Wavelength repeatability ±0.25 nm
Power-up diagnostics Optics and electronic diagnostic routine
Lamp on/off timer Remote event input, time programmable
Nano-scale flow cell design Transverse-illuminated, 10 nL
Pathlength nano 75-µm pathlength
Illuminated cell volume nanoflow 10 nL
Wetted materials 316 stainless steel, fused silica, PTFE
Pressure limit 1000 psi

Waters Acquity Binary Solvent Manager
The Waters Acquity UPLC Binary Solvent Manager delivers solvent compositions for binary gradient methods at flow rates of 0.01 to 2.0 mL per minute. The binary solvent manager's two pump channels permit quick solvent changeovers at a flow rate of 4.0 mL per minute. Low-volume degasser channels (480 µL internal volume), automated solvent-selection valves, and an automated vent valve make the quick changeovers possible. The Solvents Tray accommodates up to four chromatographic solvents, two Samaple Manager wash solvents and one Binary Solvent Manager Seal wash solvent
• In-line filters upstream of a primary check valve
• Waters Intelligent Intake Valve
• Automated priming functions
• Daily system-setup routines.
Number of Solvents Up to four
Solvent Conditioning Vacuum degassing (six-channel): one channel per solvent, and two channels for Sample Manager wash solvent
Operating Flow Range Rate 0.010 to 2.000 mL/min, in 0.001 mL increments
Compressibility Compensation Automatic and continuous
Effective System Delay Volume < 120 µL, independent of system backpressure
(with standard 50-µL mixer installed)
Plunger Seal Wash Integral, active, programmable
Gradient Profiles Eleven gradient curves [including linear, step (2), concave (4), and convex (4)]
Wet Prime Automatic
Maximum Operating Pressure 15,000 psi up to 1 mL/min, 9,000 psi up to 2 mL/min per pump,
not more than 15,000 psi total
Composition Accuracy ±0.5% absolute (full scale) from 5 to 95% of flow rates
from 0.5 to 2.0 mL/min (Contact Waters for conditions used)
Composition Precision 0.15% RSD or ±0.04 min SD, whichever is greater, based on retention time
Flow Precision 0.075% RSD or ±0.02 min SD, six replicates, based on retention time
or volumetric measures (0.500 to 2.000 mL/min)
Flow Accuracy ±1.0% at 0.5 mL/min with degassed methanol, per Waters AQT/SystemsQT protocol
Primary Wetted Materials 316 stainless steel, UHMWPE, sapphire, ruby, FEP, PTFE, ETFE,
diamond-like coating, PEEK and PEEK alloys, titanium alloys
Unattended Operation Leak sensors, full diagnostic data captured through console software

Waters Acquity Sample Manager
The Acquity UPLC Sample Manager injects the samples it draws from microtiter plates or vials into the chromatographic flow stream. A locating mechanism uses a probe to access sample locations and draw sample from them. In the needle overfill load-ahead mode, the sample manager can perform an injection in approximately 15 seconds. The first injection requires additional overhead time.
The sample manager accepts standard footprint plates (5.03 ±0.02 inch × 3.365 ±0.02 inch), that conform to ANSI standards (maximum height = 2.2 inches, including covers). You may program any combination of these plates and vial holders for automated sample processing. Samples are loaded into the sample manager via the front door or the optional sample organizer, which transfers samples back and forth between the two instruments. The sample manager can maintain samples at any temperature between 4 to 40? in 25? or less ambient conditions.
The sample temperature control is settable in 0.1? increments (assumes an ambient temperature of 25.0?). At an ambient temperature of 21.0? or lower the sample manager will maintain the temperature of the sample compartment down to 4.0? with a tolerance of -2.0/+6.0?, when configured with the maximum number of vials and/or plates.
• XYZZ based needle-in-needle design sample probe
• Loop off-line mode and load ahead advanced operations
• Unattended Operations: Leak sensors and full diagnostic data control
Number of Sample Plates Total of two plates, expandable to up to 22 plates with optional Sample Organizer (see below):
• 96 and 384 microtiter plates
• 48 position 2.00-mL vial plates
• 48 position 0.65-mL micro-centrifuge tube plates
• 24 position 1.50-mL micro-centrifuge tube plates
Maximum Sample Capacity 768 in two 384-well plates; expandable to up to 8,448 samples
with optional Sample Organizer (see below)
Number of Sample Injections 1 to 99 injections per sample
Injection Volume Range 0.1 to 50.0 µL, in 0.1 µL increments, partial or full loop mode,
10-µL loop is standard; 1, 2, 5, 20, and 50-µL loops also available
Sample Delivery Precision
(full loop injection mode) < 0.3% RSD, full loop, standard 10-µL loop (default wash/purge conditions), per Waters AQT/SystemsQT protocol
Sample Delivery Precision
(PLNO injection mode) < 1% RSD within 20% to 75% of loop volume for 1, 2, 5, 10, 20, and 50-µL loops, UV detection
Injector Linearity > 0.999 coefficient of deviation (from 20% to 75%, partial loop overfill mode
(PLNO injection mode), per Waters’ AQT/SystemsQT protocol
Sample Temperature Control 4.0 to 40.0 ?
Injection Cycle Time < 15 sec between multipe injections with “load ahead” enabled
30 sec with single weak wash, 10-µL loop, pressure assist mode
Minimum Sample Required 5 µL residual, using maximum recovery 2-mL vials (zero offset)
Wash Solvents Two degassed: strong solvent and weak wash solvent, programmable to suit application
Sample Carryover < 0.005% or < 2.000 nL, whichever is greater
Primary Wetted Materials Titanium alloy, 316 stainless steel, fluoropolymer, fluoroelastomer, PPS alloy, PEEK alloy, PPS, PEEK, DLC coating, gold

Warranty: This is a 60-day Parts only warranty. Labor charges will be the responsibility of the instrument owner. Warranty is only valid within the USA. For more details regards terms and conditions pertaining to the 60 day parts warranty and how it work inquire within.
Note: Licenses for Waters’ software products are not transferable. Any customer who purchases Waters products are advised that in order to hold a valid license to use the Waters’ software, they must purchase a license and appropriate Application Manager directly from Waters.

(1-3) Waters Synapt Mass Spectrometer (Serial Number: UAA130)

(2-3) Waters Acquity UPLC on Flex Cart
  • Waters Acquity TUV Detector (Serial Number: F12TUV406A)
  • Waters Acquity Column Heater (Serial Number: B08UPH375M)
  • Waters Acquity Sample Manager (Serial Number: C08UPA553M)
  • Waters Acquity Binary Solvent Manager (Serial Number: B08UPB447M)
  • Waters Acquity Flex Cart with Monitor and Keyboard (Computer and Software NOT Included)

    (3-3) Peak NM32LA Nitrogen Generator (Serial Number: A12-02-218)
  • 230V; 50/60Hz; 7A

  • Specifications:

    Manufacturer Name


    Serial Number:

    CE Marked:


    Type of Mass Spec:

    200-240 VOLTS
    200-240 VOLTS

    10 AMPS
    10 AMPS

    Recommended Packaging Form:


    See all item dimensions

    Item #1:
    62 x 28.00 x 56.00 IN - 0.01 LBS
    62.00 x 28.00 x 56.00 IN - 500.00 Pounds

    Item #2:
    42 x 35.00 x 70.00 IN - 0.00 LBS
    42.00 x 35.00 x 70.00 IN - 300.00 Pounds

    Item #3:
    14 x 20.00 x 16.00 IN - 0.00 LBS
    14.00 x 20.00 x 16.00 IN - 106.00 Pounds

    118 x 35 x 70 IN - 906 LBS
    2997.20 x 889.00 x 1778.00 mm - 410.96 kg

    Asset Documents

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